Chemokines in Disease, Softcover reprint of the original 1st ed. 1999
Biology and Clinical Research
Contemporary Immunology Series

Caroline Hébert and a panel of key experimentalists and clinical investigators comprehensively review the state-of-the-art in the chemokine field, ranging from the effects of chemokines and their receptors in retroviral infections, to their role in inflammation, angiogenesis/angiostasis, and tumor cell biology. The book examines in detail fifteen recently identified chemokines and elucidates the role of chemokine function in vivo from animal experiments. Animal models are also used to explore how chemokines operate in a variety of chronic and acute inflammatory diseases and in noninflammatory processes. A detailed review of the emerging role of chemokines in viral biology is also presented, with emphasis on HIV biology and novel therapeutic possibilities. Chemokines in Disease: Biology and Clinical Research summarizes the rapidly expanding knowledge of a dazzling array of chemokines and provides fresh insights into the development of powerful new drugs for treating a wide spectrum of diseases.

1. The Chemokine Gene Family: Similar Structures, Diverse Functions.- 2. Novel Chemokines Identified in Expressed Sequence Tag Databases via Bioinformatics.- 3. Understanding Chemokine Biology Through Mouse Genetics: Riddles and Answers.- 4. MCP-1 in Human Disease: Insights Gained from Animal Models.- 5. IL-8 in Animal Models of Disease.- 6. The Role of Chemokines in the Pathophysiology of the Acute Respiratory Distress Syndrome (ARDS).- 7. The Role of Chemokines in Allergic Airway Inflammation.- 8. Eotaxin in Disease.- 9. The Role of CC Chemokines in Th1- and Th2-Type Pulmonary Inflammation Models.- 10. Chemokines in Rheumatoid Arthritis.- 11. Potential Roles for Chemokines in Transplant Rejection.- 12. The Role of CXC Chemokines in the Regulation of Angiogenesis in Association with Non-Small-Cell Lung Cancer.- 13. The Role of ELR+-CXC Chemokines in Wound Healing and Melanoma Biology.- 14. Engineering, Biology, and Clinical Development of hMIP-1?.- 15. Viral Mimicry of Chemokines and Chemokine Receptors.- 16. The HIV Coreceptor Repertoire: All in the Family of Chemokine Receptors.- 17. HIV-1 Coreceptors and Viral Tropism.- 18. Mutation Analysis of Receptors and Relationship of Receptor Usage to Disease.- 19. Chemokines and Chemokine Receptors in the Brain: Function in the Normal and Pathophysiologic CNS.- 20. Antagonism of Chemokine Receptors in Preventing Infection by HIV.