Handbook of Meningococcal Disease Management, 1st ed. 2016

Coordinators: Feavers Ian, Pollard Andrew, Sadarangani Manish

Language: English
Cover of the book Handbook of Meningococcal Disease Management

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111 p. · 12.7x20.3 cm · Paperback
This concise pocketbook will provide readers with an overview and background of meningococcal disease, treatment options and emerging therapies, and methods of prevention. The book was originally commissioned due to recent developments in vaccinations to prevent meningococcal disease. This book reviews the disease progression and associated risk factors; its pathogenesis and diagnosis; methods of treatment and prevention, both current and emerging; and the future directions of meningococcal disease management. The book is ideal for busy healthcare professionals, as it covers all aspects of the disease and its treatment in a condensed and manageable format, whilst including the most up-to-date treatment guidelines and algorithms.
1. Introduction and epidemiology of meningococcal disease
Neisseria meningitidis
Disease surveillance
Case fatality and sequelae
Epidemiology of meningococcal disease
Capsular groups causing disease
Current issues
Summary points
References

2. Carriage and transmission of Neisseria meningitidis
Introduction
Detecting the carrier state
The natural history of meningococcal carriage
Epidemiology of carriage
Other Neisseria species
Effect of vaccination on carriage
Summary points
References

3. Pathogenesis of invasive disease
Introduction
Transmission, adaptation, and penetration to the circulation
Neisseria meningitidis and intravascular survival
Meningococcemia: a disease of the endothelial cells
Pathophysiological characteristics of clinical presentations of meningococcal disease
The immune response
Summary points
References

4. Diagnosis of meningococcal disease
Introduction
Conventional diagnosis
Molecular diagnosis
Typing of Neisseria meningitidis
Summary and future outlook
References

5. Clinical aspects of meningococcal disease
Introduction
Clinical spectrum of disease
Symptoms of disease
Disease outcomes and prognosis
Raising awareness of disease
Genetic factors
Summary points
References

6. Treatment of meningococcal disease
Introduction
Shock
Raised intracranial pressure
Antibiotic therapy
Adjunctive therapies
Where to manage children with meningococcal disease?
Summary points
References

7. Prevention of meningococcal disease through vaccination
Introduction
Polysaccharide vaccines
Protein-polysaccharide conjugate vaccines
Production and quality control of polysaccharide and conjugate vaccines
Immunological correlates of protection
Capsular group B vaccines
Summary points
References

Appendix
Management of bacterial meningitis in children and young people
Management of meningococcal disease in children and young people
Early management of suspected bacterial meningitis and meningococcal septicaemia in immunocompetent adults

Ian Feavers, PhD, is Head of Bacteriology at the National Institute for Biological Standards and Control (NIBSC), UK. He received his PhD from the University of Newcastle upon Tyne. After graduating he undertook postdoctoral research in molecular genetics at the University of Sheffield and the Friedrich Miescher Institut in Basel. During the late 1990s, when new conjugate vaccines were being introduced, he headed the laboratory responsible for the control and standardization of meningococcal and pneumococcal vaccines. He continues to oversee an active research program on the molecular genetics and immunology of meningococcal antigens. Because of his broad experience of bacterial vaccines and molecular biology, he has been closely involved with a number of meningococcal vaccine developments. He regularly contributes to WHO and EU guidelines, has been an advisor to the International Vaccine Institute’s typhoid conjugate vaccine initiative, and serves on the Public Health England invasive bacterial diseases forum. He is one of NIBSC’s observers on Joint Vaccination and Immunisation Committee (JCVI) and a member of the JCVI subgroups on meningococcal and pneumococcal vaccines. He is a former editor of the Journal of Applied Microbiology and is currently an associate editor of Human Vaccines and Immunotherapeutics. He has over 100 publications, including peer reviewed research papers. He teaches on vaccine related courses at the University of London, University of Surrey, and is a Visiting Professor at Imperial College.

Andrew J Pollard, FRCPCH PhD, is Professor of Paediatric Infection and Immunity at the University of Oxford, Director of the Oxford Vaccine Group, Fellow of St Cross College, and Honorary Consultant Paediatrician at the Children’s Hospital, Oxford, UK. He obtained his medical degree at St Bartholomew’s Hospital Medical School, University of London in 1989 and trained in Paediatrics at Birmingham Children’s Hospital, U

Concise pocketbook designed to support physicians, virologists, and immunologists in their day-to-day practice

Written and edited by key thought leaders and developed using the latest clinical evidence and guidelines

High quality full-color supportive illustrations, tables and graphs enable complicated concepts to be made clear to readers with different levels of background understanding